Studien zur hyperbaren Sauerstoff-Therapie

Entdecke wissenschaftliche Erkenntnisse zu HBOT

Die hyperbare Sauerstofftherapie (HBOT) wird seit Jahrzehnten erforscht und in verschiedenen medizinischen sowie leistungssteigernden Kontexten und im Wellnesbereich. Sie basiert auf dem Prinzip, Sauerstoff unter erhöhtem Umgebungsdruck einzuatmen, wodurch die Sauerstoffaufnahme im Blut und Gewebe signifikant gesteigert wird. Zahlreiche Studien haben gezeigt, dass dieser Prozess regenerative Mechanismen im Körper aktiviert und somit zahlreiche positive Auswirkungen hat.

Inhaltsverzeichnis

MECHANISM
GENERAL HEALTH
PAIN-INFLAMMATION
MITOCHONDRIA
TBI/CONCUSSION
STEM CELLS
OTHER NEUROLOGICAL
BRAIN METABOLISM

MECHANISM

Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012;45(2):316–324. doi:10.4103/0970-0358.101309

Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127 Suppl 1(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

Wingelaar TT, Brinkman P, van Ooij PJAM, et al. Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis. Front Physiol. 2019;10:475. Published 2019 Apr 24. doi:10.3389/fphys.2019.00475

A.L. Gill, C.N.A. Bell, Hyperbaric oxygen: its uses, mechanisms of action and outcomes, QJM: An International Journal of Medicine, Volume 97, Issue 7, July 2004, Pages 385–395, https://doi.org/10.1093/qjmed/hch074

GENERAL HEALTH

Fife CE, Eckert KA, Carter MJ. An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg. 2016;138(3 Suppl):107S–16S. doi:10.1097/PRS.0000000000002714

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

Fujita N, Ono M, Tomioka T, et al. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One. 2014;9(12):e115685. Published 2014 Dec 22. doi:10.1371/journal.pone.0115685

Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025

Hink J, Jansen E. Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med. Hypotheses, 57 (6) (2001), pp. 764-769.

PAIN-INFLAMMATION

Meng XE, Zhang Y, Li N, et al. Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway. Med Sci Monit. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148

Dulai PS, Gleeson MW, Taylor D, et al. (2014), Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease. Aliment Pharmacol Ther, 39: 1266-1275. doi:10.1111/apt.12753

Hui J, Zhang ZJ, Zhang X, et al. Repetitive hyperbaric oxygen treatment attenuates complete Freund’s adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord, J. Pain, 14 (7) (2013), pp. 747-758

Li F, Fang L, Huang S, et al. Hyperbaric oxygenation therapy alleviates chronic constrictive injury-induced neuropathic pain and reduces tumor necrosis factor-alpha production. Anesth. Analg., 113 (3) (2011), pp. 626-633

Choudhury R. Hypoxia and hyperbaric oxygen therapy: a review. Int J Gen Med. 2018;11:431–442. Published 2018 Nov 20. doi:10.2147/IJGM.S172460

He H, Li X, He Y. Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway. Neuropsychiatr Dis Treat. 2019;15:369–374. Published 2019 Jan 25. doi:10.2147/NDT.S183632

Wu HH, Huang CC, Chang CP, et al. Heat shock protein 70 (HSP70) reduces hepatic inflammatory and oxidative damage in a rat model of liver ischemia/reperfusion injury with hyperbaric oxygen preconditioning. Med Sci Monit. 2018;24:8096–8104. Published 2018 Nov 12. doi:10.12659/MSM.911641

Thompson CD, Uhelski ML, Wilson JR, et al. Hyperbaric oxygen treatment decreases pain in two nerve injury models. Neurosci. Res., 66 (3) (2010), pp. 279-283

Oyaizu T, Enomoto M, Yamamoto N, et al. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018;8(1):1288. Published 2018 Jan 22. doi:10.1038/s41598-018-19670-x

Zhao BS, Meng LX, Ding YY, et al. Hyperbaric oxygen treatment produces an antinociceptive response phase and inhibits astrocyte activation and inflammatory response in a rat model of neuropathic pain. J. Mol. Neurosci., 53 (2) (2014), pp. 251-261

Novak S, Drenjancevic I, Vukovic R, et al. Anti-inflammatory effects of hyperbaric oxygenation during DSS-induced colitis in BALB/c mice include changes in gene expression of HIF-1α, proinflammatory cytokines, and antioxidative enzymes. Mediators Inflamm. 2016;2016:7141430. doi:10.1155/2016/7141430

Hou S, Wu G, Liang J, et al. Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels. Oncol Lett. 2019;17(3):3277–3282. doi:10.3892/ol.2019.10000

Di Sabato F, Rocco M, Martelletti P, et al. Hyperbaric oxygen in chronic cluster headaches: influence on serotonergic pathways. Undersea Hyperb. Med., 24 (2) (1997), pp. 117-122

Bennett MH, French C, Schnabel A, et al. Normobaric and hyperbaric oxygen therapy for migraine and cluster headache. Cochrane Database Syst. Rev. (3)(2008).

Fosen KM, Thom SR. Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal. 2014;21(11):1634–1647. doi:10.1089/ars.2014.5940

MITOCHONDRIA

Palzur E, Zaaroor M, Vlodavsky E, et al. Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain Res., 1221 (2008), pp. 126-133

K.R. Dave, R. Prado, R. Busto, A.P. Raval, W.G. Bradley, D. Torbati, M.A. Pérez-pinzón,

Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in wobbler mice, Neuroscience, Volume 120, Issue 1, 2003, Pages 113-120,

ISSN 0306-4522, https://doi.org/10.1016/S0306-4522(03)00244-6.

Meyer JN, Hartman JH, Mello DF. Mitochondrial toxicity. Toxicological Sciences, Volume 162, Issue 1, March 2018, Pages 15–23.

Meyer JN, Leung MC, Rooney JP, et al. Mitochondria as a target of environmental toxicants. Toxicol Sci. 2013;134(1):1–17. doi:10.1093/toxsci/kft102

TBI/CONCUSSION

Boussi-Gross R, Golan H, Fishlev G, et al. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury – randomized prospective trial. PLoS One. 2013;8(11):e79995. Published 2013 Nov 15. doi:10.1371/journal.pone.0079995

Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508

Meng XE, Zhang Y, Li N, et al. Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of tlr4/nf-κb signaling pathway. Med Sci Monit. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148

Vlodavsky, E. Palzur, M. Feinsod, et al. Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral contusion, managed by hyperbaric oxygen therapy: a quantitative immunohistochemical study. Acta Neuropathol., 110 (2) (2005), pp. 120-126

Hadanny A, Abbott S, Suzin G, et al. Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open. 2018;8(9):e023387. Published 2018 Sep 28. doi:10.1136/bmjopen-2018-023387

Dong Y, Hu XH, Wu T, et al. Effect of hyperbaric oxygenation therapy on post-concussion syndrome [published correction appears in Exp Ther Med. 2018 Dec;16(6):4918]. Exp Ther Med. 2018;16(3):2193–2202. doi:10.3892/etm.2018.6463

Tsutsumi I, Tsujimoto Y, Takahashi S, et al. Hyperbaric oxygen therapy for persistent post‐concussion syndrome following mild traumatic brain injury. Cochrane Database Syst Rev. 2017;2017(7):CD012727. Published 2017 Jul 16. doi:10.1002/14651858.CD012727

Eve DJ, Steele MR, Sanberg PR, et al. Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Treat. 2016;12:2689–2705. Published 2016 Oct 20. doi:10.2147/NDT.S110126

STEM CELLS

Thom SR, Bhopale VM, Velazquez OC, et al. Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology-Heart and Circulatory Physiology 2006 290:4, H1378-H1386

Liska GM, Lippert T, Russo E, et al. A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells. Cond Med. 2018;1(4):151–166.

Peña-Villalobos I, Casanova-Maldonado I, Lois P, et al. Hyperbaric oxygen increases stem cell proliferation, angiogenesis and wound-healing ability of WJ-MSCs in diabetic mice. Front Physiol. 2018;9:995. Published 2018 Jul 30. doi:10.3389/fphys.2018.00995

Fosen KM, Thom SR. Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal. 2014;21(11):1634–1647. doi:10.1089/ars.2014.5940

Milovanova TN, Bhopale VM, Sorokina EM, et al. Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo. J Appl Physiol (1985). 2009;106(2):711–728. doi:10.1152/japplphysiol.91054.2008

MacLaughlin KJ, Barton GP, Braun RK, Eldridge MW. Effect of intermittent hyperoxia on stem cell mobilization and cytokine expression. Med Gas Res. 2019;9(3):139–144. doi:10.4103/2045-9912.266989

OTHER NEUROLOGICAL

Nazario J, Kuffler DP. Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma. Undersea Hyperb Med. 2011 Sep-Oct;38(5):345-66. Review. PubMed PMID: 22013761

Hu Q, Manaenko A, Xu T, et al. Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside. Med Gas Res. 2016;6(2):102–110. Published 2016 Jul 11. doi:10.4103/2045-9912.184720

Taghizadeh Asl M, Nemati R, Chabi N, et al. Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce. BMC Neurol. 2016;16:79. Published 2016 May 26. doi:10.1186/s12883-016-0605-4

M.Z. Kiralp, Ş Yildiz, D. Vural, et al. Effectiveness of hyperbaric oxygen therapy in the treatment of complex regional pain syndrome. J. Int. Med. Res., 32 (3) (2004), pp. 258-262.

Oroglu B, Turker T, Aktas S, et al. Effect of hyperbaric oxygen therapy on tense repair of the peripheral nerves. Undersea Hyperb Med. 2011 Sep-Oct; 38(5): 367–373.

Hadanny A, Efrati S. Oxygen–a limiting factor for brain recovery. Crit Care. 2015;19(1):307. Published 2015 Sep 1. doi:10.1186/s13054-015-1034-2

Hadanny A, Maliar A, Fishlev G, et al. Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. Clin Ophthalmol. 2016;11:115–125. Published 2016 Dec 29. doi:10.2147/OPTH.S121307

BRAIN METABOLISM

Front Integr Neurosci. 2017 Sep 27;11:25. doi: 10.3389/fnint.2017.00025. eCollection 2017. https://www.ncbi.nlm.nih.gov/m/pubmed/29021747/

XinwangYingabWenzhanTuabSisiLiabQiaoyunWuabXiaolongChenabYeZhouabJieHuabGuanhuYangbSongheJiangab (https://www.sciencedirect.com/science/article/abs/pii/S0024320519303753?via%3Dihub#!), Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats. Life Sciences, Volume 229, 15 July 2019, Pages 187-199

Med Gas Res. 2019 Jan 9;8(4):181-184. doi: 10.4103/2045-9912.248271. eCollection 2018 Oct-Dec. https://www.ncbi.nlm.nih.gov/m/pubmed/3071367

PLoS One. 2017 May 23;12(5):e0178182. doi: 10.1371/journal.pone.0178182. eCollection 2017. https://www.ncbi.nlm.nih.gov/m/pubmed/28542481

Mach noch heute den ersten Schritt – mit Atemwerk.

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